Instituto de Salud Carlos III (Spain)


The Instituto de Salud Carlos III (ISCIII) was created in 1986 as an autonomous public institution attached to the Spanish Ministry of Health. Its main objective is the promotion and support of research and technological development in the field of biomedicine. The general budget of the ISCIII is revised yearly by the Spanish Parliament and it has been 328.804 millions of Euros for 2007.


In the last three years, the ISCIII and the Spanish Ministry of Health have prioritized stem cell research by means of:


Banco Nacional de Líneas Celulares of Spain

Structure and objective

The National Bank of Cell Lines (Banco Nacional de Lineas Celulares, BNLC) is a network structure coordinated from the Instituto de Salud Carlos III (ISCIII), based in Madrid. Currently, the nodes are three, one in Barcelona, another one in Valencia and the central node located in Granada. Its objective is to guaranty the availability of both embryonic and adult human stem cells lines for biomedical research.

Governing principles and quality assurance

The BNCL is a non-profit organization and follows the ethical principles gathered in the international treaties related to biomedical research and human rights, acting in agreement with the principles of objectivity, collaboration, integration, and solidarity.

The BNCL is a branch of the General Subdivision of Research in Cell Therapy and Regenerative Medicine of the ISCIII, and a member of the European Human Embryonic Stem Cell Registry (hESCreg). The Technical Committee of the BNLC is the one in charge of the operational decisions and assurance of the fulfillment of ethical requisites and scientific quality in those research projects for which the lines are yielded.

What lines will be deposited in the BNLC?

The BNLC will store and supply lines of human stem cells, either embryonic or adult, with the only purpose of biomedical investigation. All the derived embryonic lines within the national territory will have to be deposited mandatorily in the BNLC.

What lines are available at the present time?

ES2, ES3, VAL-3, VAL-4 and VAL-5, all of them derived in Spain.

Who can access to a cell line from the BNLC?

The cell lines can be requested by any investigator, working in a public or private Institution, either inside or outside Spain, with a research project evaluated favorably by the Technical Committee of the BNLC.

How to proceed to request a cell line from the BNLC?

It is necessary to fill up the corresponding application form which can be downloaded from the BNLC web page: (, and send it to the following e-mail: [email protected]

The accession form should be accompanied by the report from the Ethics Committee that evaluated the research project and originals of both documents should be sent also by ordinary mail to the following address:

Banco Nacional de Líneas Celulares (BNLC)
Instituto de Salud Carlos III (ISCIII), General Subdivision of Investigation in Cell Therapy and Regenerative Medicine
Sinesio Delgado 4, 28029 Madrid, Spain

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